Head of Translational Medicine
Verge Genomics
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Posted on Wednesday, February 3, 2021
Verge Genomics is a next-generation biopharmaceutical start-up using human genomics to accelerate development of life-saving treatments for neurodegenerative diseases. Our platform uses patient tissue profiling, human genetics, and machine learning to identify new therapeutic gene targets, predict effective drugs, and stratify patient subpopulations for increased clinical success. Verge's approach offers a breakthrough opportunity to identify drugs that dramatically improve patient outcomes and fundamentally lower the cost curve of pharmaceutical development.
As the Head of Translational Medicine, you will be responsible for developing Verge’s early clinical biomarker strategy and oversee operationalization of biomarker studies in our Phase 1 trials, including the establishment of clinical and analytical lab infrastructure and key relationships. You will also drive the selection of clinical biomarkers for target engagement, patient selection, and signs of efficacy leveraging the unique insights gained from Verge’s genomics platform. The Head of Translational Medicine will also interface with the preclinical discovery teams to help drive efforts related to novel biomarker discovery using Verge's industry-leading multi dimensional discovery platform and ensure a comprehensive biomarker strategy is implemented for all preclinical discovery programs.
What You'll Do:
- Develop and execute an innovative translational medicine and biomarker strategy working across the Verge pipeline, from early discovery through clinical studies.
- Demonstrate utility/validation of markers in clinical studies, oversee the assay/method development and patient sample acquisition, assess the natural history of the marker in relevant patient samples/populations, and assess inter- and intra-patient variability .
- Serve as a leader and thought partner with preclinical colleagues to ensure alignment on a translatable biomarker strategy for all programs that advance through the pipeline. Help to identify relevant markers of target and biological pathway engagement and also disease-relevant biomarkers. Facilitate implementation of a robust series of assays to demonstrate drug effects by confirming pharmacodynamic responses in animal models and cellular assays. Acquiring and analyze translational data to guide the design of clinical studies.
- Design and oversee the use of biomarkers in clinical studies, writing protocols for incorporation of biomarkers in clinical trials, training trial sites or clinical CROs to ensure protocols are followed, overseeing the analysis of markers in clinical samples, and preparing reports suitable for regulatory documents.
- Serve as a strong external face of Verge, forming key connections with the disease community, clinical KOLs, and other partners necessary for a successful clinical trial.
What We're Looking For:
- MD/PhD, or PhD with significant early clinical and preclinical biomarker leadership experience
- At least 8+ years of industry experience, preferably in translational medicine and/or small molecule development
- Significant exposure to relevant regulatory affairs, including IND submission and FDA advisory committee meetings
- Track record of designing and executing successful early clinical biomarker programs
- Track record of success developing and executing a translational strategy from preclinical through clinical studies
- Experience leading biomarker programs in neuroscience preferred
- Strong communication skills and a track record of crafting relationships with scientific, regulatory, and clinical KOLs
- A passion for improving the lives of patients with neurodegenerative disease using genomics
- Scrappiness, resourcefulness, and desire to roll up your sleeves to get things done against all odds
Compensation & Benefits at Verge Genomics:
Our target starting salary for successful US-based applicants for this role is $164,200 to $237,900. To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, the level at which they are actually hired, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and all employees are offered Equity, subject to the terms of those plans and associated policies.
In addition, Verge Genomics also provides our employees:
*Excellent medical, dental, and vision coverage
*401(k) plan with employer matching for contributions
*Disability insurance, Life insurance, Dependant Care FSA and Healthcare FSA
*Unlimited paid time off
*Paid parental leave
*Access to free onsite fitness center
*Free snacks and lunch for employees who work onsite
*WFH stipend for employees who work remotely
Help us revolutionize the way drugs are discovered & developed:
The startup nature of Verge Genomics provides multiple growth opportunities into other areas of the company. As one of the early employees at Verge, your work will have a direct impact on the foundation of a groundbreaking new drug development model.
This job is no longer accepting applications
See open jobs at Verge Genomics.See open jobs similar to "Head of Translational Medicine" Alumni Ventures.